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Front Microbiol (2022) 13:956516
BOC Sciences designs enzyme cleavable linkers with chemical modifications, peptide sequence optimization, and structural improvements to ensure high stability in the bloodstream and non-target cells, effectively preventing premature drug release in non-target tissues
Therefore, the most accurate conclusion is balanced: GLP-1 receptor agonists can delay gastric emptying and may increase retained gastric contents in selected patients, but the absolute risk of clinically significant aspiration pneumonia remains uncertain and may be lower than initially feared in stable, asymptomatic patients
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