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Overview: Next week, Part 2 will include sections describing the effect of pharmacologic GLP-1 levels achieved via a continuous infusion of GLP-1 or via the two GLP-1 agonists exenatide or liraglutide

After entering the cochlea, cisplatin is taken up into cells by diffusive and passive transport, copper transporter protein 1 (Ctr1) and organic cation transporter protein 2 (OCT2), endocytosis, and toxicity through DNA adduct formation, oxidative stress, mitochondrial dysfunction, inflammatory response, and ferroptosis ( 2.1 Cisplatin-induced DNA damage and apoptosis Once cisplatin enters the cell it can be hydrolyzed to form toxic aqua-cisplatin complexes and form intra-and interstrand crosslinks with DNA (Mukherjea et al., 2011)

In RCTs comparing GLP-1RA and placebo, insulin doses were reduced before GLP-1RA initiation to avoid hypoglycemia, and close monitoring and insulin adjustments were done periodically

Dont tough it out if you cant keep fluids down