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Results clearly present the chemical potentiation of LASSS on physiological functions of HGF, as revealed by enhanced receptor-binding affinity and nitration-dysfunction resistance through interaction/reaction with LASSS under physiological conditions
It was shown that obesity-induced hypoxia increases the expression of miR-128, which then negatively affects INSR mRNA and protein expression levels in adipose tissue of both obese patients and high-fat diet-fed mice, correlating with the decrease in INSR expression
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