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Adding GLP-1 therapy to existing thyroid treatment requires careful medical oversight, but many patients with underactive thyroid successfully lose weight using compounds like semaglutide when prescribed under physician supervision

In AD, cerebrovascular dysfunction occurs earlier among E4 carriers (Veitch et al., 2019), which could lead to impairments in nutrient sensing and metabolite exchange between the brain and periphery, thereby negatively impacting brain bioenergetics by rendering brain areas of high energetic needs (e.g., the hippocampus) vulnerable to pathologies such as amyloid (Veitch et al., 2019