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Published data suggests that activating all three pathways simultaneously creates a synergistic effect that is meaningfully distinct from mono or dual-receptor activation alone
Clinically significant safety concerns include heart rate elevation, risk of hypoglycaemia when combined with insulin or sulfonylureas, delayed gastric emptying, and a class-relevant caution regarding thyroid C-cell tumours
bear labeling with adequate directions for use
1 Eli Lilly and Novo Nordisk have been the leaders in insulin therapies and diabetes medicines for many years, and benefit from significant scale advantages, which are evident not only in their substantial investments in developing next-generation medicines but also in their production capabilities
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