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Unlike true peptides, Dihexa is not degraded by peptidases, has a relatively small molecular weight (~480 Da), and crosses the blood-brain barrier efficiently after systemic administration
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Ru J, Li P, Wang J, Zhou W, Li B, Huang C, et al
My skin can handle a lot, so a 25% concentration of actives is no problem, but you might want to patch-test if you have sensitive skin
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