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It suggests that GLP-1 receptor agonists may protect the kidney independently of glycemic control, through direct cellular maintenance pathways an insight that bridges metabolism and organ protection (CKM axis)

At the end of the study, researchers concluded that L-carnitine had no impact on either total body mass or fat mass

In clinical trials for type 2 diabetes, nausea affected approximately 12-22% of patients depending on the dose, while diarrhea occurred in 13-16% of participants

In addition, the activation of SENP1-Sirt3 signaling leads to the accumulation of glutaminolytic -KG in M2 macrophages, which enhances M2 macrophage polarization through the demethylation of Jmjd3 at H3K27me3, thereby promoting tumor cell growth and survival in the TME (Fig