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If weight regain exceeds 35% of your lowest weight, discuss restarting or adjusting medication promptly rather than waiting for full regain

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

The medication starts at 2.5 mg weekly and increases every four weeks: Weeks 1 to 4: 2.5 mg (starting dose) Weeks 5 to 8: 5 mg Weeks 9 to 12: 7.5 mg Weeks 13 to 16: 10 mg Weeks 17 to 20: 12.5 mg Week 21 onward: 15 mg (maximum dose) At the three month mark, youve only reached the 7.5 mg dose

For cross-over experimental designs with two individual mouse populations (Fig