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Bariatric surgery offers a more drastic and immediate solution, potentially leading to significant and rapid weight loss
In clinical practice, a significant minority of patients develop constipation at each step-up, particularly at the 5-to-7.5 mg and 10-to-15 mg transitions
When a protocol requires investigation of multiple mechanisms simultaneously, sourcing each compound individually introduces additional variables: separate reconstitution conditions, independent storage requirements, and manual management of component ratios during preparation
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