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All these risk factors result in the disablement of the working of the lower oesophageal sphincter (LES) in a manner that acid flows in the opposite direction into the oesophagus
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Additionally, vascular dysfunction, endothelial dysfunction, and microclot presence may also promote vasoconstriction and tissue hypoxia
doi: 10.1096/fj.08-110759, 52 GeislerC
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