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For context, the Phase 2 study (Jastreboff 2023, NEJM) reported about 17.5 percent mean weight reduction at 24 weeks on 12 mg
Though no evidence of this has appeared in published trials
In rat models of inflammatory bowel disease, the peptide reduced inflammation, promoted mucosal healing, and improved intestinal barrier function
Animal data suggests NSAIDs may blunt some of the healing signals that BPC-157 is proposed to potentiate, specifically COX-2-mediated prostaglandin pathways that contribute to tissue remodeling
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