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Additionally, the interaction between NANOG, a gene associated with stem cells, and STAT3 increases MDR1 expression and the efflux of chemotherapeutic drugs, leading to chemoresistance development (70)

For purification, a 5 ml StrepTrap HP (GE Healthcare) was equilibrated with at least five column volumes of lysis buffer

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The subcutaneous vs intramuscular peptide injection route decision for BPC-157 is therefore often based on the specific tissue being studied rather than systemic bioavailability considerations