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It is essential to rule out clinically significant conditions such as Coeliac disease, Inflammatory Bowel Disease (IBD), or other gastrointestinal pathologies
Centrally, it also influences dopaminergic and GABAergic neurotransmitter systems, which may contribute to its observed effects on stress-related tissue damage
Cross-reactivity with other hormone assays, particularly LH, can also occur, potentially affecting evaluations of gonadotropin levels during treatment
Measuring MMA levels improves diagnostic sensitivity and specificity for cobalamin deficiency not only because Hcy elevation can occur in various conditions, but also because approximately 50% of cobalamin-deficient patients may have normal serum cobalamin levels leading to under-diagnosis (Romagnolo et al
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