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February 20, 2026
Superposition of PF-06372222-bound crystal structure (containing the C347 6.36b F mutation), with crystal structure based molecular dynamic simulations of F347 shown in blue (500 ns) and of simulations C347 (6.36b mutated back to cysteine) shown in pink (500 ns)
GLP-1 agonists act on an area in the brain that regulates appetite
The GLP-1 drugs (glucagon-like peptide-1 receptor agonists) are developed to treat both type 2 diabetes and obesity by correcting hormonal imbalance - stimulating insulin release and suppressing excess glucagon -to bring blood sugar back under control
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