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These effects are particularly noticeable in individuals with a B12 deficiency or conditions like chronic fatigue syndrome or anemia, where long-term treatment can significantly improve quality of life

Symptoms of vitamin B12 and folate deficiency anaemia include: rapid breathing or shortness of breath headaches indigestion loss of appetite palpitations problems with your vision feeling weak or tired diarrhoea a sore or red tongue, sometimes with mouth ulcers problems with memory, understanding and judgment (cognitive changes) Some of these symptoms can also happen in people who have a vitamin B12 or folate deficiency but have not developed anaemia

Its copper delivery function is biologically significant because copper is a cofactor for lysyl oxidase (essential for collagen cross-linking), superoxide dismutase (antioxidant defense), and cytochrome c oxidase (mitochondrial energy production)