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The paper concludes by proposing a unified mechanism whereby BBB dysfunction contributes to neurodegenerative disorders, highlights potential BBB-focused therapeutic strategies and targets, and outlines lessons learned and future research directions
Answer: Dihexa is thought to bind and activate the hepatocyte growth factor (HGF) receptor system, which in laboratory research is linked to neurogenesis and synaptogenesis, the formation of new neurons and new connections between them
doi:10.1007/s13277-014-1634-5 11
The compound's ability to cross the blood-brain barrier made it particularly promising for central nervous system effects
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