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Scientists are asking why. In June alone major US news and health websites joined the semaglutide frenzy with tantalising clickbait including: Could semaglutide treat addiction as well as obesity? (medscape.com) Could the diabetes drug semaglutide also help reduce alcohol use? (medicalnewstoday.com) Ozempic may help with addiction, shopping habits (healthnews.com) Weight-loss meds like Ozempic may help curb addictive behaviours (cnn.com) How semaglutide could help those with addiction disorders (abcnews.co.com) Semaglutides like Ozempic and Wegovy may treat alcohol addiction (joinalfie.com) Man who lost 80 pounds on game changer weight-loss drug also lost his desire to drink alcohol

Microbial dysbiosis has been associated with several mechanisms potentially contributing to obesity and metabolic dysfunction, including: altered energy harvest and substrate utilization from the diet modulation of gut-derived hormones involved in appetite regulation (GLP-1, PYY, ghrelin) increased intestinal permeability and metabolic endotoxemia chronic low-grade systemic inflammation impaired insulin signaling and metabolic flexibility alterations in bile acid metabolism and production of short-chain fatty acids (SCFAs) Importantly, the relationship between obesity and gut microbiota appears to be dynamic rather than causal in a linear sense