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This approach not only produces synergistic effects across these levels but also enhances drug delivery efficiency and mucosal retention through the use of natural polymeric materials, thereby comprehensively improving the efficacy of 5-ASA ( FIGURE 2 2.2 Combination of TCM formulations and 5-ASA: holistic multi-target regulation The combination of TCM formulations with 5-ASA demonstrates multidimensional synergistic advantages in clinical efficacy, mechanisms of action, and safety, significantly expanding the scope of disease management beyond conventional 5-ASA monotherapy

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Nevertheless, AMB did not affect bladder weight as well as some histological characteristics, which points to the fact that although it alleviates some effects of HC it may not prevent structural changes in the bladder ( Allium sativum Many pharmacological effects of Allium sativum garlic are mainly attributed to its major compound called diallyl disulfide (DADS)