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2B demonstrate that the p-Akt protein expression levels were significantly decreased by TNF- treatment and then increased by 1000 ug/ml L-carnitine treatment, but 100 ug/ml L-carnitine showed no effect on p-Akt

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The mechanism of action includes several key effects: Stimulating insulin secretion from the pancreas in a glucose-dependent manner, helping to control blood sugar levels Slowing gastric emptying , which prolongs the feeling of fullness after meals Reducing appetite through effects on brain centres that regulate hunger Decreasing glucagon secretion , which helps prevent excessive glucose production by the liver By targeting these multiple pathways, GLP-1 medications can lead to significant weight loss when combined with lifestyle modifications

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