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148 Hence, IR promotes the pathology of AD by reducing amyloid clearance and increasing tau hyperphosphorylation neurofibrillary tangles, 149 both of which are associated with cognitive impairment

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However, in some cases, it progresses and causes complications, such as organ failure (mainly in the liver and kidney) [6], septic shock, pulmonary edema, severe pneumonia, and ARDS, which eventually may lead to death [7]

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