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The combination yields greater weight loss than either agent alone, with mean reductions in body weight of approximately 20.4% over 68 weeks in non-diabetic adults and 13.7% in those with type 2 diabetesfar exceeding placebo and monotherapy arms
The mechanism involves multiple pathways including neutralization of reactive oxygen species, inhibition of advanced glycation end products (AGEs) formation, prevention of protein cross-linking, and stabilization of crystallin protein structures
Dobreva, A
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