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Rare sugar D-psicose improves insulin sensitivity and glucose tolerance in type 2 diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats

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The therapeutic window appears well-established at these dosing levels, with higher doses unlikely to provide proportional additional benefits while potentially increasing adverse events

Studies using supplementation of bacteria from the genus of Lactobacillus and Bifidobacterium also have similar results, pointing to the benefits of an overall diverse gut microbiota