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Activation of the gut-brain-muscle axis occurs as GLP-1 signaling engages dual circuits linking vagal afferent inputs to hypothalamic pathways, coordinating neuroendocrine outputs such as insulin-like growth factor-1 (IGF-1) signaling and sympathetic nervous system (SNS) activity that help maintain muscle mass and strength during aging [158-160]
The better we understand this, the greater the opportunity we have to improve them." The research has been published in Cell Metabolism .
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This butyrate, in turn, stimulates GLP-1 secretion by activating specific receptors on the intestinal L-cells that produce it
In summary, our study provides real-world evidence supporting the therapeutic benefits of semaglutide for AUD
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