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Clinical studies suggest that a significant proportion of weight lost during caloric restriction can come from lean tissue
PMCID: PMC7219515
The synergy means lower individual doses can be used while achieving greater total GH output
Research from the STEP trials (semaglutide) and SURMOUNT-4 (tirzepatide) shows that without ongoing pharmacotherapy or substantial behavioral interventions, significant weight regain occurs within the first year after stopping treatment
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