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Acetaminophen Toxicity and 5-Oxoproline (Pyroglutamic Acid) A Tale of Two Cycles, One an ATP-Depleting Futile Cycle and the Other a Useful Cycle Michael Emmett Summary The acquired form of 5-oxoproline (pyroglutamic acid) metabolic acidosis was first described in 1989 and its relationship to chronic acetaminophen ingestion was proposed the next year

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Experimental investigations suggest that modulation of NNMT activity may influence cellular pathways associated with energy utilization, nutrient partitioning, and metabolic adaptation