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Polymeric nanoparticles, especially those derived from PLGA (poly(lactic-co-glycolic acid)), have been used to prepare long-acting formulations of GLP-1 that can extend the release period to weeks with a single dose, reducing injection frequency and improving patient adherence [33]
Second, we performed sensitivity analyses excluding those with low MPR (selected thresholds are described previously in the section Exposure) in either metformin or study drug (GLP-1 RA or DPP-4i) during the study period
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Addressing Tolerability Issues Gastrointestinal adverse effects (nausea, vomiting, diarrhea, constipation) are the most common reasons for discontinuation
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