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NNMT inhibition increases adipose [S-adenosylmethionine (SAM)] and [Nicotinamide adenine dinucleotide (NAD+)] levels As youll discover later on in this article, theres a good reason why increased production of SAM and NAD+ within fat cells is beneficial

It is most effective as part of a structured protocol, not as a standalone fix for hair loss or systemic energy issues

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria

When this flexibility is lost, as is often seen in chronic post-viral syndromes, the body becomes locked in a state of perpetual energy debt and systemic inflammation