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Long-term safety remains under investigation
Factor #2: PCOS improvement happens faster than expected For women with PCOS, GLP-1s create a perfect storm of fertility improvement through improved insulin sensitivity (which is often the root problem in PCOS), reduced androgen levels as testosterone and other androgens drop when insulin improves, ongoing weight loss effects where each pound lost further improves hormonal balance, and potentially direct ovarian effects as some evidence suggests GLP-1s may directly improve ovarian function
Crucially, this action is glucose-dependent, meaning it primarily happens when blood sugar levels are high, such as after a meal
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