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A polymorphism in the methionine synthase reductase (MTRR) enzyme, responsible for maintaining adequate levels of cob(III)alamin, is known contribute to a moderate increase in Hcy levels (Gaughan et al., 1993)

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Molecules 29(1):136 Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra W (1973) Selenium: biochemical role as a component of glutathione peroxidase