Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program
The most commonly reported side effects are mild and transient, including injection site reactions (redness, slight swelling, or tenderness), mild headaches during the initial days of use, and occasional dizziness or lightheadedness, particularly when starting the peptide
High-dose oral B12 supplements are available over the counter for a few dollars per month, while injection visits typically involve copays, administration fees, and the time cost of repeated clinic appointments
P and GSL medicines are collectively known as Over-The-Counter (OTC) medicines