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Without this modification, a native FOXO4-based peptide would be degraded within minutes of administration
investigated the traits of cultured human retinal pigment epithelium (ARPE-19) cells exposed to NaIO 3 and observed that the process of cell death was concomitant with the deficiency of reduced thiol groups (particularly GSH and cysteine) as well as the amplified release of labile iron, which replicated the critical features of ferroptosis (85)
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