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The clinical studies have demonstrated the synergistic effects of GIP and GLP-1 agonism on glucose metabolism and body weight in these unimolecular dual agonists (63, 76), marking a significant achievement in the pharmaceutical development of incretins, which will be further discussed in the next section
Action of GLP-1 on the pancreas Physiology of GLP-1 as an incretin The primary action of GLP-1 for lowering blood glucose is the stimulation of insulin secretion by potentiating the action of glucose (20, 74, 80, 125)
Scientific References GLP-1 Receptor Agonists and Noncardiometabolic Outcomes: An Umbrella Review of Meta-Analyses
With the increase of -syn expression and the loss of dopaminergic neurons, cholesterol content and triacylglycerol hydrolysis in the brains of PD mice significantly increase
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