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When encountering elevated intracellular GSH levels, these metal-based complexes break down, triggering the targeted release of photosensitizers

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Trends Food Sci Tech 150:104597 Li X, Hu J, Zhao Q, Yao W, Jing Z, Jin Z (2024) Towards precision medicine: design considerations for nanozymes in tumor treatment

Under physiological conditions, GSH quenches oxidizing substances (such as reactive hydroxyl free radicals, peroxynitrite, and H 2 O 2 ) directly or reduces hydrogen peroxide (or lipid peroxide (lipid-OOH)) to water (or the corresponding lipid alcohol (lipid-OH)) under the catalysis of GPX (summarized in Fig