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In CD8+ T cells, an MFN2-SERCA2 axis supports ER-mitochondria calcium homeostasis and mitochondrial metabolic competence, and disruption of this module compromises effector function and antitumor immunity, while reinforcement improves therapeutic efficacy, positioning ER-mitochondria interfaces as regulatory hubs that connect chronic stimulation to durable dysfunction (50)
It requires a structured approach
Withdrawal of Approval of 92 New Drug Applications and 49 Abbreviated New Drug Applications (2009)
Most research comes from Russian scientists and has not been well replicated in Western clinical settings
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