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It acts pro-angiogenically via VEGFR2: the peptide promotes VEGFR2 internalization and activates the VEGFR2-Akt-eNOS pathway, which is blocked by the endocytosis inhibitor Dynasore, and in preclinical models it increased vessel density as well as the restoration of blood flow in the ischemic rat hindlimb Hsieh et al., 2017
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