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The preservation of normal glucose-insulin dynamics with AOD-9604 is important for appetite neutrality, as blood sugar fluctuations and insulin spikes are major drivers of hunger and cravings

Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team

Supplemental peptide therapy is designed to help restore those signals

Journal of Applied Physiology (Bethesda, Md.: 1985) , 110 (3), 774780