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MANF is predominantly situated on the luminal side of the ER, featuring a C-terminal RTDL sequence that interacts with the KDEL receptor to retain ER and Golgi membrane proteins [143]
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As weve seen with Novo Nordisks CagriSema (cagrilintide + semaglutide), which targets the amylin and GLP-1 pathways simultaneously, it outperforms Semaglutide alone
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