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The anti-inflammatory properties of NSAIDs are due to their inhibition of the cyclooxygenase (COX) enzymes , which catalyze the synthesis of localized pro-inflammatory signaling molecules called prostaglandins (Toussaint 2010)
En este sentido, se ha indicado que la apoptosis hepatocitaria, una alteracin frecuente en la EHNA70, podra activar la maquinaria fibrognica de las CEH al inducir la secrecin de TGF-, tanto por parte de las clulas de Kupffer como por las mismas CEH que fagocitan los hepatocitos apotticos112,113
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Contraindications include personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2
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