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Additionally, a case report of a child with autistic disorder and cerebral folate deficiency showed the normalisation of low cerebral spinal fluid homocysteine following 2 weeks supplementation with 0.5 mg folinic acid/kg/day increasing to 1.0/kg/day for 3 months [54]
In the first stage, tyrosinase catalyzes the hydroxylation of L-tyrosine to form L-3,4-dihydroxyphenylalanine (L-DOPA) (monophenolase activity), which is then oxidized to dopaquinone (diphenolase activity)
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