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On average, semaglutide led to a placebo-corrected weight loss of about 12%, while tirzepatide reached an impressive 18% reduction in body weight
Patients in whom heart failure (HF) or chronic kidney disease (CKD) is prevalent, should receive a treatment intensification with an SGLT-2 inhibitor with the respective evidence from clinical studies due to the respective data (7072)
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These trials showed that tirzepatide reduced fasting plasma glucose and HbA 1c levels not only compared with placebo but also compared with the insulins degludec and glargine or semaglutide [90,91,92]
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