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Its initiation is driven by iron overload, oxidative stress, inflammatory cytokines, and disrupted genetic pathways
Courier Corporation
For example, EVs secreted by cerulein-stimulated acinar cells delivered miR-183-5p, which downregulated forkhead box protein O1, promoted M1 macrophage polarization, and increased macrophage infiltration into the pancreas, ultimately leading to acinar cell injury and trypsinogen activation
Cesta CE, Rotem R, Bateman BT et al (2024) Safety of GLP-1 receptor agonists and other second-line antidiabetics in early pregnancy
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