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Santiago JA, Karthikeyan M, Lackey M, Villavicencio D, Potashkin JA
GLP-1s and Addiction The authors of GLP-1 Therapeutics and Their Emerging Role in Alcohol and Substance Use Disorders: An Endocrinology Primer , appearing in October 2025 in JES, point out that the World Health Organization reported 890 million adults and 60 million children and adolescents had obesity in 2022 globally
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Results can support a more personalized conversation between patient and provider about whether a GLP-1 monotherapy, dual-peptide strategy (e.g., GLP-Squared), or microdose protocol aligns better with identified pathway predispositions
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