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In Phase 2 trials, participants on the highest dose (12mg weekly) lost an average of 24.2% of their body weight over 48 weeks, results that surpass both semaglutide and tirzepatide at their respective trial endpoints
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Semaglutide Research Applications GLP-1 receptor pharmacology in pancreatic beta-cell lines and HEK293 cells expressing human GLP-1R, where semaglutide serves as the standard long-acting agonist for characterizing binding affinity, EC values, and downstream cAMP signaling
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