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Discovery of HPG1860, a structurally novel nonbile acid FXR agonist currently in clinical development for the treatment of nonalcoholic steatohepatitis
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Structurally, semaglutide is a modified peptide analog of human GLP-1, designed to resist enzymatic degradation and prolong its biological half-life, allowing for once-weekly subcutaneous injection
The final analysis from its Phase III clinical trials showed a 94.1% efficacy in preventing COVID-19 illness and a 100% efficacy in preventing severe COVID-19
Park SY, Choi KH, Jun JE, Chung HY
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