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In the randomized controlled trial (RCT) by Kelly et al
The pineal biology (melatonin axis) is an additional Epitalon-specific domain: Epitalon restores aged pinealocyte NAT (N-acetyltransferase) and HIOMT (hydroxyindole-O-methyltransferase) activity to 78% and 72% of young control respectively (luzindole, MT1/MT2 antagonist, partially reverses downstream circadian effects by 4452%), connecting the TERT axis to circadian biology through a pineal-specific mechanism not shared with GHK-Cu
It is hypothesized that these changes may be due to induction of cytochrome P450 2C8 by ginkgo
This helps reduce muscle fatigue and improve skin hydration
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![Structures of (a) GLP-1, (b) GIP and (c) tirzepatide [19, 88, 90]](https://www.researchgate.net/publication/370926483/figure/fig4/AS:11431281185432337@1693619320519/Structures-of-a-GLP-1-b-GIP-and-c-tirzepatide-19-88-90-Amino-acids-are.png)
