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Plasma membrane rupture in necrotic cells triggers the extracellular release of substances, including ATP, potassium ions, uric acid, high-mobility group box 1 protein, and S100 calcium-binding proteins
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2 Data suggest that plasma and hepatic GSH also are decreased in patients with acute viral hepatitis, or chronic liver injury from a variety of causes such as chronic hepatitis, nonalcoholic liver cirrhosis, and alcoholic liver disease
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