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While early and smaller trials showed promising fat-loss effects, the largest Phase IIb trial did not achieve statistical significance in humans for its primary endpoint of weight reduction, which led to the program being discontinued
Individuals who may have undiagnosed underlying conditions affecting B12 metabolism
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Animal studies in diet-induced obesity models show tesofensine treatment produces selective reduction in adiposity with improvements in insulin sensitivity, reductions in plasma lipids, and decreased accumulation of abdominal and subcutaneous fat mass
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