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In organotypic cultures of rat cortical-striatal tissue, prolonged exposure to low concentrations of QA (100 nM) for 7 weeks can induce excitotoxic injury [21]

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This approach ensures that GLP-1 therapy is tailored to those most likely to benefit from improved metabolic health, weight reduction, and reduced risk of other health conditions such as cardiovascular issues and blood sugar imbalances

Consequently, modern medical guidelines recommend pharmacological treatment when lifestyle interventions fail to achieve an adequate response