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Additionally, in a phase I study, treatment of cagrilintide (up to 4.5 mg) combined with semaglutide (2.4 mg) resulted in greater body weight reduction than semaglutide (17% vs

Key differences: Exenatide ER (Bydureon) is notable for injection site reactions, including subcutaneous nodules at the injection site caused by the microsphere formulation

Direct Myocardial Effects Although the presence of functional GLP-1 receptors on human ventricular cardiomyocytes remains a matter of debate, preclinical studies suggest potential direct cardioprotective effects