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Clinical trials studying obesity treatments often used 12-week research periods , during which modest weight loss results were observed
Long-term administration of prophylactic B12 injections is likely to elevate B12 levels, therefore harm management strategies could include - - regular monitoring of B12 levels, preferably 3-6 monthly
A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss
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